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Welcome to the lab of

Richard Daneman

UC SAN DIEGO

DEPARTMENT OF NEUROSCIENCES

DEPARTMENT OF PHARMACOLOGY

2021

CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.

Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SP, Arnold TD, Daneman R.

Nat Neurosci. 2021 Feb 1. doi: 10.1038/s41593-020-00770-9.

2020

Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes.

Pulido RS, Munji RN, Chan TC, Quirk CR, Weiner GA, Weger BD, Rossi MJ, Elmsaouri S, Malfavon M, Deng A, Profaci CP, Blanchette M, Qian T, Foreman KL, Shusta EV, Gorman MR, Gachon F, Leutgeb S, Daneman R.

Neuron. 2020 Dec 9. doi: 10.1016/j.neuron.2020.09.002


Multidimensional proteome profiling of blood-brain barrier perturbation by Group B Streptococcus.

Campeau A, Mills RH, Blanchette M, Bajc K, Malfavon M, Munji RN, Deng L, Hancock B, Patras KA, Olson J, Nizet V, Daneman R, Doran K, Gonzalez DJ.

mSystems. 2020 Aug 25. doi: 10.1128/mSystems.00368-20.


Unexpected amount of blood-borne protein enters the young brain.

Munji RN, Daneman R.

Nature. 2020 Jul. doi:10.1038/d41586-020-01791-x.


The blood-brain barrier in health and disease: important unanswered questions.

Profaci CP, Munji RN, Pulido RS, Daneman R.

J Exp Med. 2020 Apr 6. doi: 10.1084/jem.20190062.

2019

Munji RN*, Soung AL*, Weiner GA, Sohet F, Semple BD, Trivedi A, Gimlin K, Kotoda M, Korai M, Aydin S, Batugal A, Cabangcala AC, Schupp PG, Oldham MC, Hashimoto T, Noble-Haeusslein LJ, Daneman R.

Nat Neurosci. 2019 Oct 14. doi: 10.1038/s41593-019-0497-x

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation.

Weiner GA*, Shah SH*, Angelopoulos CM, Bartakova AB, Pulido RS, Murphy A, Nudleman E, Daneman R*, Goldberg JL*.

Nat Commun. 2019 Jun 6;10(1):2477. doi: 10.1038/s41467-019-10219-8.

Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties.

Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV.

Sci Adv. 2019 Mar 13;5(3):eaau7375.

2018

In Memoriam: Ben Barres

Allen NJ, Daneman R.

J Cell Biol (2018) 217 (2): 435–438.


Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.

Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, Shusta EV.

Biotechnol J. 2018 Feb;13(2).

2017

The amazing brain drain.

Blanchette M, Daneman R.

J Exp Med. 2017 Dec 4;214(12):3469-3470.

Brain barriers in health and disease.

Daneman R, Engelhardt B.

Neurobiol Dis. 2017 Nov;107:1-3.

Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior.

Hindle SJ*, Munji RN*, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R*, Bainton RJ*.

Cell Rep. 2017 Oct 31;21(5):1304-1316.

Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.

Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA.

FASEB J. 2017 Aug;31(8):3689-3694.

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism.

Meng Y, Wiseman JA, Nemtsova Y, Moore DF, Guevarra J, Reuhl K, Banks WA, Daneman R, Sleat DE, Lobel P.

Mol Ther. 2017 Jul 5;25(7):1531-1543.

2016

Finding NMO.

Daneman R.

Neurol Neuroimmunol Neuroinflamm. 2016 Dec 19;4(1):e313.

Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE.

Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM.

Exp Neurol. 2016 Sep;283(Pt A):224-34

Oligodendrocyte precursors migrate along vasculature in the developing nervous system.

Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP.

Science. 2016. Jan 22;351(6271):379-84

2015

Formation and maintenance of the BBB.

Blanchette M, Daneman R.

Mech Dev. 2015 Jul 24. pii: S0925-4773(15)30009-5

LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.

Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R.

J Cell Biol. 2015 Mar 16;208(6):703-11

The blood-brain barrier.

Daneman R, Prat A.

Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1)

2014

Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.

Nacer A, Movila A, Sohet F, Girgis NM, Gundra UM, Loke P, Daneman R, Frevert U.

PLoS Pathog. 2014 Dec 4;10(12):e1004528

Dissecting gene expression at the blood-brain barrier.

Huntley MA, Bien-Ly N, Daneman R, Watts RJ.

Front Neurosci. 2014 Nov 6;8:355

High endothelial venules through a transcriptomics lens.

Rosen SD, Daneman R.

Nat Immunol. 2014 Oct;15(10):906-8

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ.

J Neurosci. 2014 Sep 3;34(36):11929-47

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.

Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SP, Zahed H, Maltepe E, Rowitch DH.

Cell. 2014 Jul 17;158(2):383-96

Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.

Steketee MB, Oboudiyat C, Daneman R, Trakhtenberg E, Lamoureux P, Weinstein JE, Heidemann S, Barres BA, Goldberg JL.

Invest Ophthalmol Vis Sci. 2014 Jun 6;55(7):4369-77

Purification and culture of central nervous system pericytes.

Zhou L, Sohet F, Daneman R.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):581-3

Purification of pericytes from rodent optic nerve by immunopanning.

Zhou L, Sohet F, Daneman R.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):608-17

Purification of endothelial cells from rodent brain by immunopanning.

Zhou L, Sohet F, Daneman R.

Cold Spring Harb Protoc. 2014 Jan 1;2014(1):65-77

Purification and culture of central nervous system endothelial cells.

Zhou L, Sohet F, Daneman R.

Cold Spring Harb Protoc. 2014 Jan 1;2014(1):44-6

2013

Development, maintenance and disruption of the blood-brain barrier.

Obermeier B, Daneman R, Ransohoff RM.

Nat Med. 2013 Dec;19(12):1584-96

'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis.

Siegenthaler JA, Sohet F, Daneman R.

Curr Opin Neurobiol. 2013 Dec;23(6):1057-64

Foxc1 is required by pericytes during fetal brain angiogenesis.

Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ.

Biol Open. 2013 May 20;2(7):647-59

Transporters of the blood-brain and blood-CSF interfaces in development and in the adult.

Saunders NR, Daneman R, Dziegielewska KM, Liddelow SA.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):742-52

Genetic mouse models to study blood-brain barrier development and function.

Sohet F, Daneman R.

Fluids Barriers CNS. 2013 Jan 10;10(1):3

2012

The blood-brain barrier in health and disease.

Daneman R.

Ann Neurol. 2012 Nov;72(5):648-72

Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat.

Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurosci. 2012 Jul 11;32(28):9588-600

2011

Development of a method for the purification and culture of rodent astrocytes.

Foo LC, Allen NJ, Bushong EA, Ventura PB, Chung WS, Zhou L, Cahoy JD, Daneman R, Zong H, Ellisman MH, Barres BA.

Neuron. 2011 Sep 8;71(5):799-811

Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.

Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH.

J Clin Immunol. 2011 Dec;31(6):1010-20

2010

The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells.

Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA.

PLoS One. 2010 Oct 29;5(10):e13741

Pericytes are required for blood-brain barrier integrity during embryogenesis.

Daneman R, Zhou L, Kebede AA, Barres BA.

Nature. 2010 Nov 25;468(7323):562-6

2009

The gut immune barrier and the blood-brain barrier: are they so different?

Daneman R, Rescigno M.

Immunity. 2009 Nov 20;31(5):722-35

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis.

Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):641-6

2008

2005

The blood-brain barrier--lessons from moody flies.

Daneman R, Barres BA.

Cell. 2005 Oct 7;123(1):9-12

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